Detalhe da pesquisa
1.
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site.
Immunity
; 54(10): 2385-2398.e10, 2021 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34508662
2.
Rapid human genomic DNA cloning into mouse artificial chromosome via direct chromosome transfer from human iPSC and CRISPR/Cas9-mediated translocation.
Nucleic Acids Res
; 52(3): 1498-1511, 2024 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38180813
3.
A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features.
Am J Hum Genet
; 109(2): 328-344, 2022 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35077668
4.
Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice.
Drug Metab Dispos
; 52(2): 80-85, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38071551
5.
Increased propensity for infantile spasms and altered neocortical excitation-inhibition balance in a mouse model of down syndrome carrying human chromosome 21.
Neurobiol Dis
; 184: 106198, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37315904
6.
Metabolic Disposition of Triazolam and Clobazam in Humanized CYP3A Mice with a Double-Knockout Background of Mouse Cyp2c and Cyp3a Genes.
Drug Metab Dispos
; 51(2): 174-182, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36379710
7.
Significance of Basal Membrane Permeability of Epithelial Cells in Predicting Intestinal Drug Absorption.
Drug Metab Dispos
; 51(3): 318-328, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36810197
8.
A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing.
Nucleic Acids Res
; 49(7): e40, 2021 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33503245
9.
Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation.
Pharmacogenet Genomics
; 32(8): 288-292, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35997049
10.
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts.
Nature
; 538(7625): 388-391, 2016 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27723741
11.
Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.
Proc Natl Acad Sci U S A
; 116(33): 16404-16409, 2019 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31358627
12.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Proc Natl Acad Sci U S A
; 116(8): 3072-3081, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718425
13.
A New Intestinal Model for Analysis of Drug Absorption and Interactions Considering Physiological Translocation of Contents.
Drug Metab Dispos
; 49(7): 581-591, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33962977
14.
Current advances in microcell-mediated chromosome transfer technology and its applications.
Exp Cell Res
; 390(1): 111915, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32092294
15.
Transchromosomic technology for genomically humanized animals.
Exp Cell Res
; 390(2): 111914, 2020 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32142854
16.
In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice.
Xenobiotica
; 51(7): 764-770, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34013847
17.
Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.
Int J Mol Sci
; 22(6)2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33799598
18.
Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome.
BMC Biotechnol
; 20(1): 44, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32819341
19.
CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
Mol Pharmacol
; 96(5): 600-608, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31455676
20.
Generation of a novel isogenic trisomy panel in human embryonic stem cells via microcell-mediated chromosome transfer.
Biochem Biophys Res Commun
; 508(2): 603-607, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30509488